How are stem cells used to model disease in the laboratory? This 3-minute animation gives a clear, simple and visually appealing explanation of what disease modelling is, why it is useful and how it is done.
This animation was created for EuroStemCell by animator Duncan Brown, with scientific content by researcher Dr Christian Unger and voiceover by Dr Nathan Adams. It is supported by an accompanying factsheet on reprogrammed cells in disease modelling.
Reprogramming allows us to turn any cell of the body into a stem cell. Since its discovery in 2006 the technique has become widely used in labs around the world. But the process is inefficient and many questions remain about how reprogramming works. PhD student James O'Malley is studying some of these challenging issues. Here he talks about his latest findings, which were published in the journal Nature on 2 June 2013.