Animation: Disease modelling with cells

How are stem cells used to model disease in the laboratory? This 3-minute animation gives a clear, simple and visually appealing explanation of what disease modelling is, why it is useful and how it is done.

This animation was created for EuroStemCell by animator Duncan Brown, with scientific content by researcher Dr Christian Unger and voiceover by Dr Nathan Adams. It is supported by an accompanying factsheet on reprogrammed cells in disease modelling.

Reprogramming cells: new research reveals a detour on the path to iPS cells

Reprogramming allows us to turn any cell of the body into a stem cell. Since its discovery in 2006 the technique has become widely used in labs around the world. But the process is inefficient and many questions remain about how reprogramming works. PhD student James O'Malley is studying some of these challenging issues. Here he talks about his latest findings, which were published in the journal Nature on 2 June 2013.

New tools for disease research: reprogrammed cells in disease modelling

Last updated:
15 Jul 2013

We need research to understand and fight disease. But research is often limited by access to patients and availability of diseased tissues to study. 'Disease models' can help overcome these problems by enabling scientists to examine diseases in the lab. Stem cells, including reprogrammed or 'iPS' cells, are a new source of cells that can be used as models for diseases which are otherwise difficult to explore.

Folge 111: iPS-Zellen

How are iPS cells created in the laboratory? Short film in German.

Für die bahnbrechende Entwicklung von induzierten pluripotenten Stammzellen wurde 2012 der Medizin-Nobelpreis vergeben. Wie genau iPS-Zellen im Labor entstehen, erklärt Jan Wolkenhauer in der 111. Folge der Kreidezeit.

Schools across Scotland discuss stem cell research

On the 10 December 2012, while John Gurdon and Shinya Yamanaka were being awarded their Nobel Prize in Stockholm, Scottish biology teachers and their students were enthusiastically joining the celebrations by taking part in EuroStemCell’s BIG View of Stem Cells! 

New stem cell film: an introduction to iPS cells

The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent".

STEM CELLS - THE FUTURE: AN INTRODUCTION TO IPS CELLS by Amy Hardie and Clare Blackburn tells the story of this extraordinary scientific discovery that has changed the way we think about human biology.

We celebrate the Nobel Prize with global film screenings

On 10 December 2012, this year's Nobel Prizes will be awarded in an official prize-giving ceremony in Stockholm. Stem cell researchers all over the world reacted with delight a few months ago when the Nobel committee announced its decision to award this year's Nobel Prize in Physiology or Medicine to John B. Gurdon and Shinya Yamanaka for work that has revolutionised cell biology.

Now scientists, museums and cinemas from Stockholm to Sydney are joining with members of the public to celebrate the Nobel Prize with special public screenings of the documentary Stem Cell Revolutions.

Stem cells - the future: an introduction to iPS cells [video]

Last updated:
26 Nov 2012

In this compelling and clear 16 minute video, leading scientists tell the story of induced pluripotent stem cells (iPS cells) - an extraordinary scientific discovery that changed the way we think about human biology and saw Shinya Yamanaka awarded the Nobel Prize for Medicine, with John Gurdon, in 2012.

Types of stem cells and their current uses

Last updated:
17 Aug 2012

Stem cell research is often in the news; whether it's claims of new therapies or controversies about the types of cells used. What is the true potential of stem cells behind the headlines? How valuable are they as tools for research and therapy? And what are the advantages and limitations of different types of stem cells for different uses?

A new short cut for stem cell programming

Researchers at the University of Bonn artificially derive brain stem cells directly from the connective tissue of mice

Scientists at the Life & Brain Research Center at the University of Bonn, Germany, have succeeded in directly generating brain stem cells from the connective tissue cells of mice. These stem cells can reproduce and be converted into various types of brain cells. To date, only reprogramming in brain cells that were already fully developed or which had only a limited ability to divide was possible. The new reprogramming method presented by the Bonn scientists and submitted for publication in July 2011 now enables derivation of brain stem cells that are still immature and able to undergo practically unlimited division to be extracted from conventional body cells. The results have now been published in the current edition of the prestigious journal Cell Stem Cell.

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