Clinical trials news: January 2012 update

Before new treatments can reach patients, they must be tested in clinical trials. This is our second brief update on some stem-cell-related trials currently under way or recently approved.

What's covered in this update?

This update looks at trials for amyotrophic lateral sclerosis (ALS) or motor neurone disease, as well as the latest news on how the trials we told you about in September are progressing. We’ve included details of one or two new trials for some of the conditions we focussed on last time: spinal injury, Stargardt’s macular dystrophy and stroke. We’ll post more updates on other themes in future, so tell us if there’s an area you really want to know about.

 

About clinical trials

Clinical trials are carried out in four phases:

  • Phase I and Phase II trials check on safety – they make sure the treatment does no harm to patients. 
  • Phase III or IV trials focus on assessing how effective the treatment is, and developing it into a therapy that can be made widely available.

Amyotrophic lateral sclerosis (ALS) or motor neurone disease

ALS trial in Atlanta, USA

The company Neuralstem Inc and researchers at Emory University in Atlanta, USA have received approval from the Food and Drug Administration (FDA) to advance to the second stage of their trial investigating the safety of using human neural stem cells to treat patients with amyotrophic lateral sclerosis (ALS). Amyotrophic lateral sclerosis is also known as motor neurone disease, or sometimes Lou Gehrig’s disease. In ALS, the nerve cells that control movement degenerate and die. These nerve cells are found both in the spinal cord and in the brain.

The Neuralstem Inc/Emory clinical trial started in January 2010 and is designed to assess the safety of implanting neural stem cells derived from human fetal tissue into the spinal cord in up to 18 people with ALS. The first 12 patients received neural stem cells in the lumbar, or lower, region of the spinal cord. Following a review of the safety data in autumn 2011, the FDA granted approval to transplant neural stem cells in the cervical (upper) region of the spinal cord.

Key facts

Phase and objective: This is a phase I trial. The objective is to evaluate the feasibility and safety of transplanting human spinal-cord-derived neural stem cells into the spinal cord of patients with amyotrophic lateral sclerosis.
Dates: January 2010 – October 2012
Enrollment status: Recruiting. 12 patients already recruited. Aims to enroll up to18 patients.
More information on this study
More about Amyotrophic Lateral Sclerosis

ALS trial in China

The State Food and Drug Administration in China authorised a phase II trial on the use of umbilical cord mesenchymal stem cells in amyotrophic lateral sclerosis. The cells will be injected by lumbar puncture: a hollow needle is inserted between the bones of the lower back into the fluid around the lower part of the spinal cord. The trial is being run by the General Hospital of Chinese Armed Police Forces. The researchers hope that the injected stem cells will release small proteins called trophic factors that help keep motorneurons healthy and working properly.

Key facts

Phase and objective: This is a phase II trial. The objective is to evaluate the safety and efficacy of transplanting umbilical cord mesenchymal stem cells by lumbar puncture into patients with ALS.
Dates: January 2012 – April 2015  
Enrollment status: Not yet open for participant recruitment. Aims to enroll up to 30 patients.
More information on this study
More about Amyotrophic Lateral Sclerosis

 

Progress news on trials from our last update

In our September 2011 clinical trials update we described trials for macular degeneration, spinal injury and stroke. Some of these trials have moved forward or stopped, and additional trials are getting underway for some of these conditions. Below is an update on progress.

Stargardt’s macular dystrophy

In September we told you about a safety study being carried out by the company Advanced Cell Technology (ACT) in the USA for patients with advanced Stargardt’s macular dystrophy. ACT now has authorization to start a trial in the UK using the same type of cells as in the US. These cells are called retinal pigment epithelium (RPE) cells and are made from human embryonic stem cells. The UK trial will be a phase I/II study and will be carried out at the Moorfields Eye Hospital NHS Foundation Trust in London, UK.

Key facts

Phase and objective: This is a phase I/II trial to evaluate the safety and tolerability of transplanting retinal pigment epithelial cells derived from human embryonic stem cells into the eye.
Dates: November 2011 – December 2013.
Enrollment status: Recruiting. Aims to enroll up to 12 patients
More about this study
More about Stargardt’s disease
September 2011 clinical trials update from EuroStemCell

Spinal cord injury

Geron trial

In October 2011, Geron presented the safety data from four patients who received the lowest intended dose of cells called GRNOPC1 in the company’s phase I clinical trial for spinal injury. The cells did not cause any serious problems. However, in November 2011 Geron announced it is halting this trial to focus on other areas of research. 

Press release from Geron about it’s first results from the trial
News article on halting of this trial

StemCells Inc. trial

In December 2011, StemCells Inc announced that the first cohort of patients with chronic spinal injury had been transplanted with human central nervous system stem cells (HuCNS-SC) produced by the company. This phase I/II trial is taking place at the Balgrist University Hospital in Zurich in Switzerland and started in March 2011. Its aim is to evaluate the safety of transplanting HuCNS-SC cells into the spine of patients with chronic spinal injury. The trial is currently recruiting patients and the company has opened up enrollment to include patients in the USA and Canada.

Press release from Stem Cells Inc on progress and patient enrollment
Previous clinical trials update from EuroStemCell

New spinal injury trial in India

The US and Indian company TotipotentRX is conducting a study in India using bone marrow stem cells in spinal injury patients.  The stem cells will be derived from the patient’s bone marrow and transplanted back into the spine.  This is known as an autologous transplant – the transplanted cells come from the patient’s own body. It is hoped that the bone marrow stem cells will help reduce the extent of damage to tissues after spinal injury, and encourage repair of nerves.

Key facts

Phase and objective: This is a phase I/II trial. The objective is to evaluate the of autologous bone-marrow-derived stem cell transplantation in patients with spinal cord injury. A secondary objective is to look for evidence of a positive effect of the transplant.
Dates: October 2011 – October 2013
Enrollment status: Recruiting. Aims to enroll up to 15 patients.
More information on this study
More about spinal cord injury

Stroke

ReNeuron trial

ReNeuron’s pilot study of it’s neural stem cell therapy ReN001 for stroke patients started in June 2010 at the Institute of Neurological Sciences at Glasgow University and has now recruited 6 patients. In late October 2011, the data collected from the first four patients were reviewed by the trial independent data safety board and no cell-related problems have been reported to date. ReNeuron expects that all remaining patients in the clinical trial will be treated over the course of 2012. 

Press release from ReNeuron about the trial's progress

 

Find out more

Acknowledgements

Christine Kubiak from ECRIN researched and helped put together this update.
Lead image: ©iStockphoto.com/Photo-Dave

Your feedback

Is this update useful? Is it easy to read and detailed enough? What else would you like to know about?  Add your comments below or use our contact form to send us feedback.

Multi-level degenrative disc disease and stem cell treatment

Hi, are there any clinical trials in the uk for stem cell treatment to repair multi-level disc degeneration? And do you know why midwives are not instructed to routinely ask if a woman wants to donate cord blood after the birth of her baby? Many thanks. Sam

Clinical trials in the UK

Hi Sam, thanks for your comment. Have you seen our FAQ on participating in clinical trials, which  includes links to several searchable clinical trials databases, as well as links to futher information on the clinical trials process? The UK Clinical Trials Gateway may also be of interest.

There is some information on umbilical cord blood in our FAQ on this topic:

See also the NHS Choices page on cord blood donation.

I hope this info is helpful, thanks again for getting in touch.  Kate

clinical trials for demyelination children

Hi My son aged 31/2 has demyelination, which affects his balance - he can not walk without assistance, his speech is impaired only 3/4 words and his fine motor skills are affected. Is there any clinical trials ongoing for demyelination in children, we would be very interested in getting our son on one in europe or USA etc. Could you email me please. I would really appreciate any input.Regards Sabrina

Your enquiry about demyelination trials

Dear Sabrina,


Thanks for getting in touch, I'm really sorry to hear about your son's illness.


Have you seen our fact sheet on multiple sclerosis? It includes some information about current research on possible ways to tackle myelination that may be useful. You can read it here: Multiple sclerosis and stem cell research fact sheet

If you are considering enrolling your son in a clinical trial, we do recommend that you discuss this with your doctors in the first instance. You can find more information about where you can search for clinical trials and advice on trials participation in our FAQ on clinical trials.

I hope this information is useful. If you have further questions, do get in touch via our Contact form and we will do our best to help with further information by email.
Wishing you and your son all the very best,
Emma

hearing loss

hello, my son age 4 years suffering with profound hearing loss due to high fever,before fever his speech and hearing normal. iam intresting with stem cell therapy,this treatment can help my son s hearing loss cure. for this treatment do you know where will be the best place to have it. i heared about bekie bio science in china is doing stem cell treatment for hearing loss. iam not sure where to go for this treatment. can you help me more information about this treatment, for my child hearing loss cure thank you suresh kumar

Your enquiry about hearing loss

Hi Suresh,

I'm very sorry about your son's fever and hearing loss.

Have you seen our information about what stem cell treatments are currently proven and available? You can find it in our FAQ here: What diseases and conditions can be treated with stem cells? 

I am afraid we cannot recommend treatments or clinics. Stem cell therapies are generally at an early stage of research and development. Much more work is needed before safe and effective treatments can be made available to restore damaged hearing. There is some information here that will help you assess the reliability of any treatment you may have been offered: I have been offered a stem cell treatment, should I go ahead with it?

If you have more questions, please do get in touch using our contact form and we will do our best to help by email.

With best wishes to you and your family,

Emma

ALS (MND)

My mom 64 years is diagnosed with ALS last jan. Can stell cell therapy cure her?

Your enquiry about ALS/MND

Hi,

I'm really sorry to hear about your mum's condition. I'm afraid there are no approved therapies for ALS using stem cells yet. You can read an overview of current stem cell research into treatments for MND in our fact sheet, Motor neurone disease: how could stem cells help?

You can also find a good overview of what diseases currently have proven and available stem cell treatments in our FAQ here: What diseases and conditions can be treated with stem cells? 

If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

With best wishes to you and your family, Emma

stem cell treatment for Locked in Syndrome?

My brother in law is suffering from "Locked In Syndrome" following a major stroke last year. I have heard that stem cell treatment could possibly help. As he is only 28 we as a family are, after a year of no improvement & having been given no hope by the hospital here, now looking for information regarding any treatment that may improve, even slightly, one or another aspect of his life. I understand that some clinical trials have been conducted at the Glasgow southern General Hospital in conjunction with ReNeuron regarding possible treatment of stroke victims. Can you give me any information on what stage these trials are now at? I can find no information more recent than November 2011 as mentioned in your article above & no mention of possible research into LIS specifically if there has been any (?) Thank you in advance for ANY information or pointers you might be able to give. Chris.

stem cell treatment for Locked in Syndrome?

My mother is suffering from "Locked in syndrome" following a major stroke too. We are searching any informations about clinicals trials who may be adapted for her. Could you please guide me? Thank you in advance,

your answer

Dear Lila,
Thank you for your comment. I am sorry to hear of your mother's condition. You might find some useful information on our factsheet about stroke here: http://www.eurostemcell.org/factsheet/stroke-how-could-stem-cells-help. You can also find more information about clinical trials in the FAQ and patient links on our clinical trials page: http://www.eurostemcell.org/clinical-trials
If you have further questions, please feel free to get in touch with us using our patient enquiry form: http://www.eurostemcell.org/contact
All the best,
Christele

update on ReNeuron stroke trial

Hi Chris, thanks for getting in touch. I'm sorry to hear about your brother in law's condition. 

There is some updated information about the ReNeuron stroke trial on the company's website, including information about plans for a phase II trial. Our FAQ on stem cells and stroke gives an overview of current research directions and may also be of interest.

Approved stem cell treatments so far only exist for a very small number of diseases.  You can find a good overview of what treatments are proven and available in our FAQ here: What diseases and conditions can be treated with stem cells? 

If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

Wishing you and your family all the best, Kate

Cerebral stroke

Stem cell research of America have been treating patients extremely successfully. They say they are much more advanced in their research and treatment of stroke problems. In Scotland there appears to be much more caution, and any potential cure may be years away. Apart. From the cost, there appears to be a choice of immediate help, or a long wait at home. I am tempted by the American claims. Do you have any comments??

stem cells for stroke

Hi Robert, thanks for getting in touch. 

Approved stem cell treatments so far only exist for a very small number of diseases.  You can find a good overview of what treatments are proven and available in our FAQ here: What diseases and conditions can be treated with stem cells? Our FAQ on stem cells and stroke might also be of interest.

Stem cell therapies are generally at an early stage of research and development. More work is needed before safe and effective treatments can be made available for a condition such as stroke. If you have been offered treatment, please take a look at our FAQ, 'I have been offered a stem cell treatment, should I go ahead with it?' This includes information and links to help you assess the reliability of any offers of treatments or clinical trials that may be made to you. We also recommend that you discuss any decisions of this type with your doctor.

I hope this helps. If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

Best wishes, Kate

Wish

thanks for this nice post, very helpful post for me and think all.

Hello,I am hard of hearing

Hello, I am hard of hearing and read that stem cell can help to restore my hearing back. Do you know where will be the best place to have it ? or Will it help me? I heard people in China are heaaring better now but I am not sure where to go or where to get more safe information. Thanks a lot and blessing for your help.

You question about hearing

Hi Silvia,

Thanks for getting in touch, I'm sorry you're having hearing problems.

Approved stem cell treatments so far only exist for a very small number of diseases.  You can find a good overview of what treatments are proven and available in our FAQ here: What diseases and conditions can be treated with stem cells?

Many researchers are investigating the possibility of stem-cell-based treatments to restore hearing, but this type of research is at the very early stages. For example, we recently reported on some research published by scientists at the University of Sheffield: http://www.eurostemcell.org/story/embryonic-stem-cells-could-help-restore-hearing

I hope this helps. If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

Best wishes, Emma

spinal cord injury

Hi there I'm writting to you regarding the spinal cord stem cell studies, I'm 19 year old lad who is paralized chest downward due to fall from balcany last year , I'm looking for help to get my sensation back and hopefully I walk again one day ,when I read about the stem cell they gave me hope and I seen that you looking for injured people that going to take part in studies , I be glad if I be one off them or at least guide me in the right direction , please email me back because it means alot to me, I do have MRI scan done in england last month when I visited my brother over there .if you do require sending the cd to give you better idea then I will do as soon as you get back intouch thank you for your time , your sincerely Hamza

Your enquiry about spinal cord injury

Hi Hamza. Thanks for your comment, I'm really sorry to hear about your injury. EuroStemCell is not directly involved in research, treatments or clinical trials. We are a group of people who work in stem cell research, and have set up the website to provide more information about stem cell research in Europe.

Have you already seen our fact sheet Spinal cord injury: how could stem cells help? It gives a good overview of current research and clinical trials looking at using stem cells to treat spinal cord injury.

We described on three spinal cord injury trials in the article above. The Geron trial has stopped. The Stem Cells Inc trial is a very small trial for 12 patients within 3 to 12 months of being injured. If you would like to know more about this trial, you can contact Stem Cells Inc via their website. The trial in India is described in more detail here: http://clinicaltrials.gov/ct2/show/NCT01490242?term=NCT01490242&rank=1

Outside of the approved clinical trials process, some companies offer stem cell related treatments for patients with spinal cord injuries, without significant evidence that the treatments they offer have been successful. Anyone considering paying for such a treatment is encouraged to discuss it with their physician, and to read this information document prepared by a group of spinal cord injury doctors:Experimental Treatments for Spinal Cord Injuries: What you should know if you are considering participation in a clinical trial
I hope this information is useful. If you have more questions, please get in touch by email using our Contact form and we will do our best to answer them.

All the best,
Emma

wondering what embryotic stem cell research truly is?

i am a pro life person and i was wondering how this stem cell researsch thing really is a good thing i think we have a enough of information with just using adults. I feel it is unnecessary to use embryotic stem cells. Life begins at conception!!!!! I feel it is murder to use the cells of aborted babies to cure dieseases.

Re wondering what embryonic stem cell research is

Dear Molly,

Many thanks for your comment. Many people hold strong views on this topic, and of course each of us must make our own decision about what we believe. EuroStemCell hopes that by providing accurate, up-to-date information on what stem cell research is about and how it is being used, we can help people to reach an informed decision on the topic of embryonic stem cell research, whatever that decision may be.  You may find some of the following information useful:

- FAQ on embyronic stem cell research, describing what embyronic stem cells are, how they are currently used, and what the challenges are for this type of stem cell research in relation to work on other types of stem cells

- Fact sheet on ethics and embryonic stem cells, 'Embryonic stem cells: and ethical dilemma'

- Fact sheet on the science of embryonic stem cells, 'Embryonic stem cells: where do they come from and what can they do?'

I hop e this information is useful and thanks for sharing your views.

Emma

i had no idea..

hi emma, first and foremost, i'd like to thank you for the efforts you have taken to clear up on the doubts of embryonic stem cell research. i had no idea it really meant utilizing a life (pardon me, although the term itself was a dead giveaway), are there any other comparable alternatives to embryonic cells? it sounds really terrible and almost like taking an innocent's life away.. i would really like to know more on the pros and cons of this embryonic cells vs other cells. this is too hard for me to take..

Re i had no idea...

Thank you for taking the time to comment. In addition to the links Emma lists above, you might also be interested in reading the following information elsewhere on our website:

I hope this information is useful. Best wishes, Kate

 

9 year old with cerebral palsy

hi, my 9 year old son has cerebral palsy on his right side of the body, his arm and leg is shorter than his left side. his arm is always tight and folded in and hand is in a tight fist, he is bent forward in the knees and his foot is on flat when standing but is turned in, so he walks on the outside of his foot. can stem cell him, please

9 year old with cerebral palsy

Hi. Thanks for getting in touch, I'm sorry to hear about your son's cereral palsy.

Approved stem cell treatments so far only exist for a very small number of diseases.  You can find a good overview of what treatments are proven and available in our FAQ here: What diseases and conditions can be treated with stem cells?

You can find more information specifically about stem cell research and cerebral palsy in a fact sheet available on the Childhood Disability Link website here: Fact sheet on stem cell treatments for cerebral palsy (pdf)

If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

Best wishes, Emma

stem cell therapy for neuro foot

hi my dad is diabetic and also suffers from neuro foot. he has an open wound for the last 4-5 years which does not heal and we have tried nearly everything. i know stem cell therapy is being used for treating that but not able to find a lot of information about it. would you be able to guide whether stem cell therapy can be used to treat neuro foot and where the treatment is available in UK or India. thanks tarun

stem cell therapy for neuro foot

Hi Tarun, thanks for leaving a comment. I'm sorry to hear about your dad's foot condition.

At the moment there are very few approved stem cell treatments.  Our FAQ: What diseases and conditions can be treated with stem cells? gives a good overview of what stem cell treatments are currently proven and available.

If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

Best wishes, Kate

info abt retina treatment

My father having retinal problem due to this problem he see 50% in daylight and night he cant see properly plzzz tell me the solution of this problem...................where the treatment are done???plzzz give me detail information.............

your enquiry about retina treatment

Hi Ms Zuby, thanks for your enquiry.

We recommend that if your father is concerned about his condition he discusses it with his doctor. Following are some information resources on this website that might be helpful to you:

If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

Best wishes, Kate

CP for one yr old

My 15 month old has been diagonsed with CP and Hypertonia. Can you tell me any stem cell trials out there for CP for children. I did not save her cord blood but have looked into stem cell reasearch and found some information. Please help any information would be amazing. Thank you Heather

Your enquiry about CP

Hi. Thanks for your comment, I’m sorry to hear of your child's illness. Have you seen our information on 'What diseases and conditions can be treated with stem cells?' You can read it here: http://www.eurostemcell.org/faq/what-diseases-and-conditions-can-be-treated-stem-cells. It gives a good overview of what stem cell treatments are currently proven and available.

Stem cell therapies are generally at an early stage of research and development. More work is needed before safe and effective treatments can be made available for a condition such as cerebral palsy. If you have been offered treatment for your child, please take a look at our information, 'I have been offered a stem cell treatment, should I go ahead with it?' This will give you support on how to assess the reliability of any offers of treatments or clinical trials that may be made to you. We also recommend that you discuss any decisions of this type with your child's doctor.

If you have more questions, please do get in touch using our contact form and we will do our best to help with further information by email.

SMD and AMD hESC clinical trials

It's been almost a year sine your last update on these two trials. Are there any progress? Thanks

Your enquiry about SMD and AMD hESC clinical trials

Hi. Thanks for getting in touch. The company Advanced Cell Therapy (ACT) sent out a press release about their progress in July this year. You can read the press release on the Reuters website. The company is also keeping information about its trials up-to-date in the database clinicaltrials.gov. The links to the trials in the database are:

You may also find this article in the Guardian newspaper interesting: http://www.guardian.co.uk/science/2012/jun/04/stem-cell-first-human-trials . It gives an overview of some key current stem cell clinical trials and includes comments from Prof Pete Coffey, who is involved in a trial for age-related macular degeneration.

I hope this helps. We're currently developing a new strategy for how to provide information about clinical trials. We'd be very interested in your views on what type of information is useful and what format you would like it in. Please do send us your comments using our contact form.

Hi, my father had a stroke in

Hi, my father had a stroke in september 2011 where he had a bleed in the pons area of the brain. It has been 9 months and he is bed bound although he still has movement in all limbs but weakness in left side. He has slurred speech and vision has been affected. he was getting better straight after the stroke but then developed the side affect of vomiting, whih caused him to get chest infections (asporation pheumonia) many times and urine infections which made him terribly weak and so he could not recover. I was wondering if he could be part of your trials. He has poor trunk muscles as well. I look forward to hearing from you. Kind Regards Neha Thapar

Stroke trial enquiry

Hi Neha and thanks for your comment. I'm sorry to hear about your father. We are not running any clinical trials at EuroStemCell, our work is all about providing reliable information about stem cell and regenerative medicine research. The stroke trial mentioned in the article above is being run by the company ReNeuron. It is a very early stage trial with 12 patients to test the safety of a possible approach to treating stroke. There is some further information about the trial on the ReNeuron website. You might also find our FAQ, What is stroke and can stem cells help? useful. If you still have questions, you can get in touch with us by using our Contact form. I hope this helps. All the best, Emma.

Cerebral Palsy

Hello Do you know if there will be any clinical trials for Cerebral Palsy? I have a 6 year old nephew withe CP and his mum and dad are looking into Stem Cell treatment. I'm sure they would be interested in a clinical trial. Kind regards Charlotte

cerebral palsy & clinical trials

Hi Charlotte, Thanks for your comment - I've sent you some information by email. I'd also recommend taking a look at our FAQ on clinical trials and stem cell treatments.
Best wishes, Kate

CLINICAL TRIAL

Hi, My goddaugther had a car accident on June 19th 2006 and she has been paraplegic since this date. She will have 10 years old end of April and I was wondering whether she could be candidate for the next phase of your clinical trial. Or if not, would you have any suggestion how to help her ? Some more information about her situation as of today : her spinal cord has not been completly broken, she has been injured because of an effusion at T11. She has never been operated on. She considered as paraplegic today. She can walk few minutes with crutches but not for long as she becomes very tired quickly. She is catheterized five times a day. She does not feel anything under her ankle and so she could not move her feet. From her knees she has some feelings but not on all parties. The quadriceps femoris is 100% OK but her bottom muscle is very weak. One week after the accident she has been received intensive remedial gymnastics and since she has been continuing gymnastics. I really hope that she could participate to your next phase of clinical trial or you could advice us as today we don’t know how to help her to get better. Many many thanks for your kind help. Very kind regards, Eszter HOGYESZI-MAGYAR

clinical trials for spinal cord injury

Hi Eszter, thanks for your comment. I'm sorry to hear about your goddaughter, and I have responded in more detail by email. I'd also recommend taking a look at our FAQ about clinical trials and stem cell treatments. All the best, Emma.

cranial facial neuropathy

I've had cranial facial neuropathy for 12 years. I'm looking for a clinical trial that wouls accept me but I don't seem to fit into any of the very specific trials that are being conducted. Is there any hope of a trial for people who are suffering from neuropathy that doen't fall into your specific disease categories? Is there another place you could direct me to that might be doing research in nerve regeneration? Hoping for help, Zoe A. Hess

clinical trials for neuropathy

Hi Zoe, thanks for your comment. I've responded separately by email. I'd also recommend taking a look at our FAQ about clinical trials and stem cell treatments. All the best, Kate.

Post new comment

The content of this field is kept private and will not be shown publicly.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Allowed HTML tags: <a> <em> <strong> <cite> <code> <ul> <ol> <li> <dl> <dt> <dd>

More information about formatting options