Autism research using mini-organs grown from patient derived stem cells

Autism is a complex neurodevelopmental disorder whose causes are not fully understood. Recent work by scientists at Yale University has shown that organoids – miniature three-dimensional organ buds – grown from stem cells could help shed some light on autism spectrum disorder (ASD).

Stem cells and equine health

Last updated:
27 Feb 2015

Horse owners and veterinary practitioners are increasingly considering stem cells as an alternative treatment option - for problems such as tendon and ligament injuries, where standard veterinary treatments are not effective. This is particularly the case for high-value sport horses. And because the use of cell therapies in animals sits outside of the strict regulatory frameworks for human medicines, veterinary stem cell companies have proliferated, selling treatments that have yet to be properly tested.

Challenges in autism research

This is the second in a series of blog posts looking at stem cells and autism, by PhD student Jamie Reilly. If you missed it, check out his first post, Why I chose to research stem cells. 

In this post, Jamie takes a closer look at some of the key questions and challenges in autism research today, and how stem cells might help. Read on for more about:

Studying the genetics of autism spectrum disorder
Source of cells: blood versus brain
Looking at the system: a systems biology approach
Where do stem cells fit? 

Studying the genetics of autism spectrum disorder

The complex nature of the genetics of Autism Spectrum Disorder (ASD) is just one of the many challenges in researching this topic. In the past decade we have found candidate genes implicated in many areas, such as the growth and development of neuronal cells, regulation of signalling molecules involved in the immune system, and mitochondrial function.

Spotlight on... induced pluripotent stem cells

This month we take a closer look at iPS cells and reprogramming 

Over the past four years we've developed and collected lots of information and resources about stem cells. This month we turn the spotlight on induced pluripotent cells (or iPS cells). First discovered by Shinya Yamanaka in 2006, iPS cells are made from adult specialised cells using a laboratory technique called reprogramming.

Animation: Zellen als Krankheitsmodelle

Wie werden Stammzellen als Labormodell für Krankheiten genutzt? Dieser vierminütige Animationsfilm erklärt einfach und anschaulich, wie und wieso Zellen als Krankheitsmodelle genutzt werden.

Diese Animation wurde im Auftrag von Eurostemcell von Duncan Brown produziert. Der wissenschaftliche Inhalt, sowie die Stimme, wurde von Dr Dr Christian Unger zur Verfügung gestellt. 

Dieses Video ist inhaltlich mit dem "factsheet on reprogrammed cells in disease modelling" verbunden (auf Englisch, deutsche Fassung in Entwicklung).

Stem Cell Research: Trends and Perspectives on the Evolving International Landscape

New report on stem cell research reveals the field is growing twice as fast as the world average.

Stem Cell Research: Trends and  Perspectives on the Evolving International Landscape presents a comprehensive analysis of the growth and development of the stem cell field, with particular focus on embryonic stem (ES) cell and induced pluripotent stem (iPS) cell research outputs. The report was jointly prepared by Elsevier, Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and EuroStemCell, and will be discussed on 6 December 2013 at the World Stem Cell Summit in San Diego.

StemCellShorts - What are induced pluripotent stem cells?

The third in a series of short (around 1 minute) animated films that answer basic questions about stem cell research.

Celebrated by the 2012 Nobel Prize in Medicine, a type of cell known as an "induced pluripotent stem cell" or "iPS cell" has important implications for the emerging field of biomedical technology. In this video, Canadian scientist Dr. Mick Bhatia explains how iPS cells are created and how they can be used to create new therapies for human disease.

For a more detailed look at iPS cells, and accompanying resources, see Stem cells - the future: an introduction to iPS cells.

Stem cells - the future, le futur, die Zukunft, il futuro, nasza przyszłość, el futuro

We're excited to announce that our short film, Stem cells - the future: an introduction to iPS cells, is now available in six languages and with a supporting quiz for the classroom. You can now order a DVD or view the film online and download the quiz, all in your language.





Renowned experts offer advice on generating human induced pluripotent stem cell banks

Procedures for production of induced pluripotent stem (iPS) cells for use in therapy are reaching the point at which they will be suitable for use in clinical trials.
A team of internationally renowned scientists led by the MRC Centre for Regenerative Medicine’s Emeritus Professor Sir Ian Wilmut have today published an opinion piece in the journal CellStemCell, arguing that while in the future it might be possible to derive iPS cell lines on an individual basis – so that a patient would receive his or her own cells as a treatment – it seems unlikely that these will be used as a source for large numbers of patients in the near future due to time and cost restraints.

Scottish Stem Cell Stories: A graphic short story of stem cell research

Last updated:
26 Sep 2013

Making blood from stem cells, iPS cells from skin cells and improving the lives of those with diabetes are just a few of the stories that are touched on in this delightful comic. A colourful and enticing introduction to some of the stem cell research happening in Scotland and the directions the science is taking. Ideal for use in the classroom, at festivals and events.

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