research

Neue Hilfsmittel zur Erforschung von Krankheiten: Umprogrammierte Zellen zur Modellierung von Krankheiten

Last updated:
15 Jul 2013

Um Erkrankungen zu verstehen und erfolgreich zu bekämpfen muss Forschung betrieben werden. Jedoch wird diese oft durch eingeschränkten Zugang zu Patienten oder dem fehlenden Vorhandensein von erkranktem Gewebe, erschwert oder unmöglich gemacht. 'Krankheitsmodelle' können diese Probleme umgehen indem sie Wissenschaftlern ermöglicht Krankheiten im Labor zu überwachen. Stammzellen, besonders sogenannte induzierte pluripotente Stammzellen (iPS Zellen), ermöglichen es Wissenschaftlern Krankheiten, für die es bisher kaum Studienmaterial gab, im Labor zu modellieren und daraus neue Erkenntnisse zu gewninnen. 

Managing the potential and pitfalls of emerging stem cell therapies

While blood stem cells have been used clinically for over 40 years, it was the discovery of human embryonic stem cells in 1998, that has built expectations for people affected by a multitude of degenerative, chronic and fatal diseases with no cures or effective treatments. The speed with which therapies were expected to roll out of the lab did not take into consideration the complete lack of infrastructure required to make it happen, for many turning potential into frustration.

Nuovi strumenti per la ricerca medica: Cellule riprogrammate come modello di patologie

Last updated:
15 Jul 2013

Abbiamo bisogno della ricerca per comprendere e combattere le malattie; ma spesso la ricerca é limitata dalla difficoltà di accesso a pazienti e dalla ridotta disponibilita di tessuti. L’utilizzo di ‘Modelli di malattie’ aiua a superare questo problema permettendo ai ricercatori di studiare le malattie in laboratorio. Le cellule staminali, incluse le cellule riprogrammate (o cellule ‘iPS’), sono una nuova fonte di cellule che possono essere usate come modello per malattie che sarebbero altrimenti difficili da investigare.

MERLIN

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MEsenchymal stem cells to Reduce Liver INflammation (MERLIN) is a four year project that will bring leading European researchers in stem cells and liver disease together with global industrial partners to look at new ways to treat liver disease with stem cells. MERLIN will specifically focus on primary sclerosing cholangitis (PSC), an inflammatory liver disease currently without effective treatments, but will also generate new knowledge that is more widely applicable to stem cell therapy in general.

Paralysie cérébrale : Que peuvent apporter les cellules souches ?

Last updated:
10 Mar 2014

La paralysie cérébrale touche environ deux enfants sur mille en Europe, et est le handicap physique le plus fréquent de l’enfance. Elle est responsable d’un large éventail de symptômes, parmi lesquels figurent des troubles de la marche et de la coordination des mouvements. Aucun remède n’a encore été découvert. Les cellules souches pourraient-elles donc aider ?

Identité cellulaire et reprogrammation

Last updated:
3 Oct 2014

Notre organisme contient plusieurs centaines de types différents de cellules spécialisées. Chaque cellule a des caractéristiques très spécifiques qui lui permettent de remplir son rôle. Pourtant, toutes les cellules de votre organisme contiennent les mêmes gènes – le même ‘manuel d’instructions’ biologique. En quoi chaque type de cellule est-il donc différent ? Et pouvons nous contrôler ou modifier les identités cellulaires ? Comment cela pourrait-il nous aider à développer de nouvelles approches en médecine ?

Study reveals the genesis of brain cells that degenerate in Huntington’s disease

Elena Cattaneo reports on recent research that examines how a particular type of cell develops in the human brain, and how studies like this fit into the overall picture of research collaboration and funding, in Italy and in Europe.

It took 4 years of continuous experiments of 17 researchers from 6 groups in 2 European countries to understand more about how cells develop in the striatum. The striatum is the area of the brain that degenerates in Huntington’s disease (HD) – a neurological disorder that as of today, has no cure. This work, led by my group at the University of Milan, was published in Nature Neuroscience on 10 Nov 2014.

Making insulin producing beta cells from stem cells – how close are we?

The unseen world: Insulin-producing cells made from human embryonic stem cellsThe unseen world: Insulin-producing cells made from human embryonic stem cells

Two recent studies have revealed for the first time how to to generate insulin producing cells, that resemble normal beta cells, in the lab from human pluripotent stem cells. This provides a step forward for a potential cell therapy treatment for diabetes. But how alike are these cells to the beta cells found in our bodies? How close are we to testing these cells in diabetics? And what other questions still remain? In this commentary, Henrik Semb tackles these questions providing perspective in this complex and challenging field.

Investigación y terapia con células madre: tipos de células madre y sus aplicaciones actuales

Last updated:
17 Aug 2012

La investigación con células madre es un tema de actualidad en los medios de comunicación; o bien por sus nuevas aplicaciones terapéuticas o bien por los polémicos debates respecto al tipo celular usado. ¿Pero cuál es el auténtico potencial de las células madre detrás de todos estos titulares? ¿Son realmente buenas herramientas para la investigación y para la terapia celular? ¿Cuáles son las ventajas y las limitaciones del uso de diferentes tipos celulares en distintas aplicaciones?

Infarto: Cómo pueden ayudar las células madre?

Last updated:
22 Apr 2014

El ataque o derrame cerebral es la segunda causa mortal en el mundo y la principal causa de invalidez en Europa. El derrame ocurre cuando el flujo de sangre que va al cerebro se ve alterado y, como consecuencia, una parte del cerebro deja de recibir oxígeno y nutrientes, lo que a menudo provoca manifestaciones severas en otras partes del cuerpo. Dependiendo del tamaño del derrame y donde se produzca, cerca de una tercera parte de las víctimas de un derrame cerebral se recuperan, aunque la mayoría sufre algún tipo de consecuencias permanentes y algunos derrames pueden provocar una discapacidad severa. Pueden las células madre ayudar en el tratamiento de los derrames cerebrales?

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