research

Organoids for personalized cancer treatment

Two studies published in Nature and Cell this month show that organoids, miniature organs that can be cultured in a dish, could be crucial for personalized treatment of cancer.

GSCN video: Andreas Trumpp (EN)

In this short video by the German Stem Cell Network, scientist Andreas Trumpp talks about his research on cancer stem cells.

In German, dubbed into English.

GSCN video: Magdalena Götz (EN)

Magdalena Götz from the Helmholtz Zentrum München is a leading researcher in the field of neuronal stem cells.

In this video, produced by the German Stem Cell Network, she talks about her work. In German, dubbed into English.

Repair-HD

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Repair-HD researchers are taking on the complex task of exploring cell replacement therapy in HD over the next four years. Funded under the Seventh Framework Programme (FP7), the project aims to enable efficient translation of experimental stem cell therapies to preclinical work in small and large animal models, and readiness for clinical application.

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Neue Hilfsmittel zur Erforschung von Krankheiten: Umprogrammierte Zellen zur Modellierung von Krankheiten

Last updated:
15 Jul 2013

Um Erkrankungen zu verstehen und erfolgreich zu bekämpfen muss Forschung betrieben werden. Jedoch wird diese oft durch eingeschränkten Zugang zu Patienten oder dem fehlenden Vorhandensein von erkranktem Gewebe, erschwert oder unmöglich gemacht. 'Krankheitsmodelle' können diese Probleme umgehen indem sie Wissenschaftlern ermöglicht Krankheiten im Labor zu überwachen. Stammzellen, besonders sogenannte induzierte pluripotente Stammzellen (iPS Zellen), ermöglichen es Wissenschaftlern Krankheiten, für die es bisher kaum Studienmaterial gab, im Labor zu modellieren und daraus neue Erkenntnisse zu gewninnen. 

Managing the potential and pitfalls of emerging stem cell therapies

While blood stem cells have been used clinically for over 40 years, it was the discovery of human embryonic stem cells in 1998, that has built expectations for people affected by a multitude of degenerative, chronic and fatal diseases with no cures or effective treatments. The speed with which therapies were expected to roll out of the lab did not take into consideration the complete lack of infrastructure required to make it happen, for many turning potential into frustration.

Nuovi strumenti per la ricerca medica: Cellule riprogrammate come modello di patologie

Last updated:
15 Jul 2013

Abbiamo bisogno della ricerca per comprendere e combattere le malattie; ma spesso la ricerca é limitata dalla difficoltà di accesso a pazienti e dalla ridotta disponibilita di tessuti. L’utilizzo di ‘Modelli di malattie’ aiua a superare questo problema permettendo ai ricercatori di studiare le malattie in laboratorio. Le cellule staminali, incluse le cellule riprogrammate (o cellule ‘iPS’), sono una nuova fonte di cellule che possono essere usate come modello per malattie che sarebbero altrimenti difficili da investigare.

MERLIN

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MEsenchymal stem cells to Reduce Liver INflammation (MERLIN) is a four year project that will bring leading European researchers in stem cells and liver disease together with global industrial partners to look at new ways to treat liver disease with stem cells. MERLIN will specifically focus on primary sclerosing cholangitis (PSC), an inflammatory liver disease currently without effective treatments, but will also generate new knowledge that is more widely applicable to stem cell therapy in general.

Paralysie cérébrale : Que peuvent apporter les cellules souches ?

Last updated:
10 Mar 2014

La paralysie cérébrale touche environ deux enfants sur mille en Europe, et est le handicap physique le plus fréquent de l’enfance. Elle est responsable d’un large éventail de symptômes, parmi lesquels figurent des troubles de la marche et de la coordination des mouvements. Aucun remède n’a encore été découvert. Les cellules souches pourraient-elles donc aider ?

Identité cellulaire et reprogrammation

Last updated:
3 Oct 2014

Notre organisme contient plusieurs centaines de types différents de cellules spécialisées. Chaque cellule a des caractéristiques très spécifiques qui lui permettent de remplir son rôle. Pourtant, toutes les cellules de votre organisme contiennent les mêmes gènes – le même ‘manuel d’instructions’ biologique. En quoi chaque type de cellule est-il donc différent ? Et pouvons nous contrôler ou modifier les identités cellulaires ? Comment cela pourrait-il nous aider à développer de nouvelles approches en médecine ?

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